Scheda di Offerta Tesi

Titolo (provvisorio): Definition and validation of source localization methods in Stereotactical EEG recordings

Relatore/i: Fato Marco Massimo, Gabriele Arnulfo E-mail:
Indirizzo: Viale Causa 13 - Piano -1 Tel.: (+39) 010 33 52789

Motivazione e campo di applicazione
StereoEEG is a highly invasive recording method used in the characterization of the epileptogenic zone in patients affected by partial epilepsy. SEEG records local field potentials from ~5 mm of cortical tissue. Recently, several lines of evidence suggest that LFPs are not “so local”, and they indeed rise concerns about the geometrical resolution yielded by linear shafts. These call for the usage of advanced methods for source reconstruction also in the case of intracerebral electrodes.

Obiettivi generali e principali attività
The aim of the proposed thesis is to define, construct, and validate a pipeline to reconstruct neural sources from Stereotactical EEG recordings only. The project will:
Explore state of the art forward and inverse problem solvers
Define the set of tools that most reliably reconstruct real source locations
Implement these tools in a standardized pipeline
Validate the pipeline using simulated as well as real data (with and without internal stimulation)
The thesis is expected to yield a validated set of tools that are able to perform source localization starting from resting-state SEEG data.

Obiettivi di apprendimento (strumenti tecnici e analitici, metodologie sperimentali)
The candidate will learn to handle publicly available source localization softwares largely used in the neuroscience community. He will also investigate the mathematical methods behind forward and inverse problem solutions (e.g. BEM and FEM-based methods or LORETA,sLORETA and MNE). The candidate will improve his programming skill using matlab.

Luogo/i in cui si svolgerà il lavoro: Biolab - Unige

Informazioni aggiuntive

Abilità e capacità richieste: Matlab

Numero massimo di studenti: 1

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