Scheda di Offerta Tesi

Titolo (provvisorio): Bioactive electrospun scaffolds for tissue engineering of vascular grafts

Relatore/i: Pastorino Laura, Patrizia Perego (DICCA) E-mail:
Indirizzo: Via Opera Pia 13 Tel.: (+39) 010 33 56547

Motivazione e campo di applicazione
Design, fabrication and characterization of tubular scaffolds prepared by electrospinning for the replacement or bypass of damaged arteries in various cardiovascular diseases.

Obiettivi generali e principali attività
There is great clinical demand for synthetic vascular grafts with improved long-term efficacy. An ideal vascular conduit should be easily implanted, non-thrombogenic, biocompatible, resistant to aneurysmal dilatation and biodegradable as the patient remodels the graft into tissue resembling native vessel. In this respect, the electrospinning technique will be used to fabricate biocompatible and biodegradable optimized conduits, which will be further bioactivated by their loading with bioactive molecules (e.g. antioxidants) in order to minimize inflammation at the site of implant.

Obiettivi di apprendimento (strumenti tecnici e analitici, metodologie sperimentali)
To gain practical experience in the development, engineerization and characterization of a drug loaded bioplolymeric tubular scaffold obtained by electrospinning technique.

Luogo/i in cui si svolgerà il lavoro: DIBRIS, DICCA, University of Genoa

Informazioni aggiuntive

Numero massimo di studenti: 1

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