CORSO DI LAUREA MAGISTRALE IN BIOINGEGNERIA

Scheda di Offerta Tesi

Titolo (provvisorio): Nano-in-micro drug formulations for cystic fibrosis

Relatore/i: Pastorino Laura E-mail:
Indirizzo: Via Opera Pia 13 Tel.: (+39) 010353 - 6547
Descrizione

Motivazione e campo di applicazione
Design, fabrication and characterization of drug delivery systems able to overcome the limitations of current therapeutic protocols in the treatment of cystic fibrosis (CF)

Obiettivi generali e principali attività
Chronic pulmonary infections by Pseudomonas aeruginosa are characteristic of CF patients, which are currently treated by antibiotics. However, the efficacy of such treatment protocols in CF patients is limited by the overproduction of a viscous and highly complex mucus, which limits drug bioavailability and targeting at the site of infection. In this respect, functionalized nanoparticle-based drug delivery systems will be specifically developed to overcome the mucus barrier. Moreover, the developed nanoformulations will be encapsulated in micro-containers for their efficient pulmonary delivery though inhalation.

Obiettivi di apprendimento (strumenti tecnici e analitici, metodologie sperimentali)
To gain practical experience in the development and engineerization of a multifunctional system to overcome a specific problem starting from the knowledge of the pathophysiological characteristics of a diseased tissue.

Luogo/i in cui si svolgerà il lavoro: DIBRIS, University of Genoa

Informazioni aggiuntive

Numero massimo di studenti: 2

Sei qui: Home Proposte Tesi Magistrale