Thesis Project Form

Title (tentative): The relation between the (hypoxia induced) lack of activity and eventual cell death, investigated using optogenetics

Thesis advisor(s): Martinoia Sergio E-mail:
Address: Phone: (+39) 010 33 52251

Motivation and application domain
thesis project developed @Biomedical Signal and Systems Lab, University of Twente (NL)

General objectives and main activities
We will infect cultures with a virus that induces channel- and / or halorhodopsins in a well-defined group of neurons (excitatory). This creates the possibility to selectively excite or inhibit neurons. We will monitor the effect of excitation during hypoxia and inhibition during normoxi on the recovery/ viability of cultured corticalneurons.

Training Objectives (technical/analytical tools, experimental methodologies)
Use of micro electrode arrays and systems for data acquisition
Development of experimental protocols
Data analysis of multisite neurophysiological data
Development of new algorithms

Place(s) where the thesis work will be carried out: University of Twente

Additional information

Maximum number of students: 1

Financial support/scholarship: Erasmus +

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