CORSO DI LAUREA MAGISTRALE IN BIOINGEGNERIA

Scheda di Offerta Tesi

Titolo (provvisorio): Poly-lactic acid nanoparticles as platforms for protein conjugation for applications in drug delivery

Relatore/i: Pastorino Laura, , Orietta Monticelli (DICCI) E-mail:
Indirizzo: Via Opera Pia 13 Tel.: (+39) 010353 - 6547
Descrizione

Motivazione e campo di applicazione
Design, fabrication and characterization of protein delivery systems able to overcome the limitations of current delivery protocols

Obiettivi generali e principali attività
The in vivo delivery of proteins presents some problems related to their susceptibility to denaturation and poor bioavailability. In order to solve these problems, the delivery by their conjugation to nanocarriers is required. In this respect, biocompatible and biodegradable polymeric nanoparticles will be prepared by nanoprecipitation and functionalized in order to promote their conjugation with therapeutic proteins. The developed nanoformulations will be encapsulated in micro-containers for their efficient in vivo delivery.

Obiettivi di apprendimento (strumenti tecnici e analitici, metodologie sperimentali)
To gain practical experience in the development and engineerization of a multifunctional system to overcome problems related to the in vivo delivery of therapeutic proteins.

Luogo/i in cui si svolgerà il lavoro: DIBRIS, DICCI

Informazioni aggiuntive

Numero massimo di studenti: 1

Sei qui: Home Proposte Tesi Magistrale